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On the Search of Metallated Sulfonamides: Synthesis and X‐ray Characterization of the New Sulfathiazolato Nickel(II)‐Chelate Complex [Ni(STZ)2(Py)2]·2Py (STZ = Sulfathiazolato Anion; Sulfathiazole = N1‐2‐thiazolyl‐sulfanilamide; Py = Pyridine) |
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| Authors: | Gelson Manzoni de Oliveira Prof. Dr. Lara Regina Soccol Gris Lenice de Lourenço Marques Ernesto Schulz Lang |
| Affiliation: | 1. Santa Maria, RS / Brazil, Universidade Federal de Santa Maria, Departamento de Química, Laboratório de Materiais InorganicosDepartamento de Química, Laboratório de Materiais Inorganicos, Universidade Federal de Santa Maria, 97105‐900 Santa Maria, RS / Brazil;2. Santa Maria, RS / Brazil, Universidade Federal de Santa Maria, Departamento de Química, Laboratório de Materiais Inorganicos |
| Abstract: | Sulfathiazole (HSTZ) reacts with triethylamine and Ni(CH3COO)2·4H2O in methanol and further with pyridine to give the sulfathiazolato complex [Ni(STZ)2(Py)2]·2Py. In the new chelate complex the deprotonated sulfonamidic nitrogen atom does not take part in the coordination process, apparently retaining the negative charge. Two (STZ)? moieties are symmetrically bonded to the Ni2+ ion through a thiazolyl nitrogen atom and an oxygen atom of the S(O)2 group. Two pyridine molecules accomplish the fairly distorted octahedral coordination at the metal centre. |
| Keywords: | Nickel Sulfathiazole complexes Bioinorganic chemistry Metallation Biological ligands |