Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives |
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| Authors: | Kaffy Julia Pontikis Renée Florent Jean-Claude Monneret Claude |
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| Affiliation: | UMR 176 CNRS, Institut Curie-Section de Recherche, 26 rue d'Ulm, 75248 Paris cedex 05, France. |
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| Abstract: | Stereospecific syntheses of the Z-E and E-Z vinylogues of combretastatin A-4, and two B-ring related analogues, were achieved through a Suzuki-Miyaura coupling. As compared to CA4, the derivative with a phenyl moiety has shown increased potency in its ability to inhibit tubulin polymerisation. |
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