Solid state reactions of nitrogenous heterocyclic compounds (II) |
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Authors: | Xiaoliu Li Yongmei Wang Daming Du Zhong Wen Guoxiang Xiong Jiben Meng |
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Institution: | (1) Department of Chemistry, Nankai University, 300071 Tianjin, China |
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Abstract: | Solid state Michael addition reaction of indole with α, β-unsaturated carbonyl compounds was carried out, by which a series
of compounds containing three different heterocyclic groups binding to one carbon atom were ob-tained. In the presence of
Lewis acid, indole could undergo the solid state condensation reaction with aromatic ketones and aldehydes or quinones. The
solid state reaction showed higher selectivity and yield than solution reaction. The structures of products were identified
by IR,1H NMR, MS. elemental analysis and X-ray crystal analysis. The reac-tion mechanism was also proposed.
Project supported by the National Natural Science Foundation of China |
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Keywords: | solid slate reaclion nitrogenous compound indole Michael addition reaction |
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