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Design,synthesis and use of binary encoded synthetic chemical libraries
Authors:John J. Baldwin
Affiliation:(1) Pharmacopeia Inc., 101 College Road, 08540 Princeton, NJ, USA
Abstract:Summary With the advent of combinatorial chemistry a new paradigm is evolving in the field of drug discovery. The approach is based on an integration of chemistry, high-throughput screening and automation engineering. The chemistry arm is usually based on solid-phase synthesis technology as the preferred approach to library construction. One of the most powerful of the solid-phase methods is encoded split synthesis, in which the reaction history experience by each polymeric bead is unambiguously recorded. This split-and-pool approach, employing chemically robust tags, was used to construct a 85 000-membered dihydrobenzopyran library.
Keywords:Library construction  Split synthesis  Split-and-pool  Dihydrobenzopyran library
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