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A turn-on fluorescent probe for Au3+ based on rodamine derivative and its bioimaging application
Authors:FengLing Song  HouFu Ning  HaiYing She  JingYun Wang  XiaoJun Peng
Institution:1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, China
2. School of Life Science & Biotechnology, Dalian University of Technology, Dalian, 116024, China
Abstract:A new fluorescent probe RY was synthesized for the detection of Au3+ ions based on a rhodamine B derivative. The fluorescent probe showed good selectivity and sensitivity to Au3+ ions. Obvious color and fluorescence changes could be observed with the naked eye while the fluorescent probe reacted with the Au3+ ions. The detection limit of the probe was determined to be 36 ppb by the fluorescence titration; the excellent linear relationship suggests that the probe is potentially useful for quantitative detection of Au3+ in vitro. We also demonstrated its bioimaging application in both living cells and mice; this was the first time that a fluorescent probe was successfully applied to imaging Au3+ in living animals.
Keywords:turn-on  gold ion fluorescent probe  low detection limit  good selectivity and sensitivity  bioimaging application
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