Some recent advances in transition-metal-catalyzed ortho SP~2 C–H functionalization using Ru,Rh, and Pd |
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基金项目: | supported by the National Basic Research Program of China(2011CB965300);the National Natural Science Foundation of China(21142008,21302106);Tsinghua University 985 Phase II Funds,and the Tsinghua University Initiative Scientific Research Program |
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摘 要: | In the past decade,transition-metal-catalyzed C–H functionalization by weak coordination has emerged as a practical and powerful tool to access many valuable chemicals.Two classes of weakly coordinating directing groups,commonly occurring functional groups,and easily removable auxiliaries,have been found to be efficient and practical for C–H activation reactions.This mini-review contains examples of recent research advances on transition-metal-catalyzed SP2 C–H functionalization via weak coordination,using Ru,Rh,and Pd.A number of weakly coordinating functional groups(e.g.,ketone,ester,carbamate,tertiary amide,ether,thioether,alcohol,and some others)are covered.As the field of transition-metal-catalyzed C–H functionalization continues to develop and more synthetically useful chemo-,regio-,and enantioselective reactions catalyzed by transition metal via weak coordination are discovered,this promising and attractive strategy will play a more important role in modern organic synthesis.
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关 键 词: | transition metal catalysis SP C–H functionalization weak coordination ortho-selectivity directing group |
Some recent advances in transition-metal-catalyzed ortho SP2 C-H functionalization using Ru,Rh, and Pd |
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Authors: | Yu Rao Gang Shan XingLin Yang |
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Institution: | 1. MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, 100084, China
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Abstract: | In the past decade, transition-metal-catalyzed C-H functionalization by weak coordination has emerged as a practical and powerful tool to access many valuable chemicals. Two classes of weakly coordinating directing groups, commonly occurring functional groups, and easily removable auxiliaries, have been found to be efficient and practical for C-H activation reactions. This mini-review contains examples of recent research advances on transition-metal-catalyzed SP2 C-H functionalization via weak coordination, using Ru, Rh, and Pd. A number of weakly coordinating functional groups (e.g., ketone, ester, carbamate, tertiary amide, ether, thioether, alcohol, and some others) are covered. As the field of transition-metal-catalyzed C-H functionalization continues to develop and more synthetically useful chemo-, regio-, and enantioselective reactions catalyzed by transition metal via weak coordination are discovered, this promising and attractive strategy will play a more important role in modern organic synthesis. |
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