Adsorption of liposomes and emulsions studied with a quartz crystal microbalance |
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| Institution: | 2. Department of Electrical and Biomedical Engineering, University of Nevada, Reno, Reno, NV 89557-0260, United States;3. Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, United States;1. G.E.T.E.F., Departamento de Física Aplicada, Facultad de Ciencias, Universidad de Valladolid, Paseo de Belén, 7, 47011 Valladolid, Spain;2. Departamento de Ingeniería Electromecánica, Escuela Politécnica Superior, Universidad de Burgos, Avda. Cantabria s/n, 09006 Burgos, Spain |
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| Abstract: | The adsorption from phospholipid liposome solutions (1.2%) and phospholipid stabilized oil-in-water emulsions (20% purified soybean oil) with the same phospholipid liposome concentration, has been followed by means of a quartz crystal microbalance allowing the simultaneous determination of changes in resonance frequency and energy dissipation. Both the fundamental resonance frequency and the third overtone were used for following the interfacial processes. The adsorption from the liposome solution resulted in formation of a phospholipid bilayer with an additional and incomplete outer layer of liposomes. The outer layer was removed by dilution leaving a bilayer of phospholipids on the surface. The adsorption process observed from the concentrated emulsion solution was considerably more complex. A slow spreading process that also resulted in some expulsion of material from the interface followed the rapid initial adsorption of emulsion droplets. After rinsing with water a phospholipid bilayer was retained on the surface. |
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