Study on disulfur-backboned nucleic acids:Part Ⅳ.Efficient synthesis of 3',5'-dithio-2'-deoxyguanosine |
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基金项目: | supported by the National Natural Science Foundation of China(No.20872078);;the Basic Science Research Foundation of Tsinghua University(No.JC 2001046) |
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摘 要: | <正>An efficient and novel method for synthesizing 3′,5′-dithio-2′-deoxyguanosine was described.In this method normal guanosine was used as the starting material.A very efficient procedure was used to synthesize 2-O-tosylguanosine 1,which used 0.1 eq.DBTO instead of 2 eq.1 was treated with LTBH to give 9-(2-deoxy-β-D-threo-pentofuranosyl)guanine 2.2 could be easily turned to the target compound.
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关 键 词: | 3′ 5′-Dithio-2′-deoxyguanosine Guanosine Synthesis |
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