Photorepair of Ultraviolet Radiation (UVR)-lnduced Pyrimidine Dimers in Lens Epithelial DNA of Monodelphis domestica |
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| Authors: | Gregory B. Tafoya James M. Gale Ronald D. Ley |
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| Affiliation: | Photomedicine Program, Institute for Basic and Applied Medical Research, The Lovelace Institutes, Albuquerque, NM, USA |
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| Abstract: | Abstract— The repair of UV radiation-induced pyrimidine dimers has been measured in lens epithelial DNA of the marsupial Monodelphis domestica using a pyrimidine dimerspecific endonuclease from Micrococcus luteus. Approximately 40% of the initially induced dimers were repaired during 90 min exposures to photoreactivating light. This capacity of the lens epithelium to photorepair pyrimidine dimers may provide a means with which to determine whether pyrimidine dimers in lens epithelial DNA are involved in UV radiation-induced pathologic changes of the lens. |
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