In Vivo EPR Imaging of a Perfluoroalkyl Radical in Mouse Abdomen |
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Authors: | H Yokoyama T Ono T Yoshimura |
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Institution: | (1) National Institute of Advanced Industrial Science and Technology, Nagoya, Japan;(2) Yamagata Promotional Organization for Industrial Technology, Yamagata, Japan |
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Abstract: | Although it is thought that perfluoro-2,4-dimethyl-3-isopropyl-3-pentyl (PFR-2) is a candidate for electron paramagnetic resonance
(EPR) imaging agents because of its high stability, no study has been made yet on the EPR imaging of PFR-2. In this study,
EPR imaging of a phantom including PFR-2 and mice that had received PFR-2 was performed by an in vivo EPR imaging system operating
at an EPR frequency of 700 MHz equipped with a bridged loop-gap resonator (inner diameter, 41 mm; axial length, 10 mm). Because
PFR-2 is insoluble in water, it was dissolved in perfluorocarbon. The PFR-2 solution was put in cylindrical sample tubes with
various inner diameters, and these sample tubes were placed together in a larger cylindrical sample tube filled with a physiological
saline solution, which was used as a phantom. The spatial resolution was estimated to be about 3 mm on the basis of EPR imaging
of the phantom. EPR images of mice that had received a PFR-2 injection via the intraperitoneal route indicated that PFR-2
remained in the peritoneal cavity even 2 days after the injection. This finding suggests that it is possible to perform EPR
imaging of experimental animals using PFR-2 as an imaging agent which persists in a biological system.
Authors' address: Hidekatsu Yokoyama, National Institute of Advanced Industrial Science and Technology, 2266-98 Anagahora,
Shimoshidami, Moriyama-ku, Nagoya, Aichi 463-8560, Japan |
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Keywords: | |
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