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Unsymmetric-1,3-disubstituted imidazolium salt for palladium-catalyzed Suzuki–Miyaura cross-coupling reactions of aryl bromides |
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| Authors: | Hong-Wei Yu Ji-Cheng Shi Hong Zhang Peng-Yu Yang Xin-Ping Wang Zi-Lin Jin |
| Institution: | aState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China bState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China |
| Abstract: | A series of 1-(ferrocenylethyl)-3-substituted-imidazolium salts 3-substitute = 2,6-di(iso-propyl)phenyl (1a), 2,4,6-trimethylphenyl (1b), tert-butyl (1c), 1-Ad (1d), cyclohexyl (1e)] have been synthesized from a racemic ferrocenylethyl acetate and the corresponding N-substituted imidazole in high yields (70–94%). A combination of Pd(OAc)2 and 1a–d was found to form an excellent catalyst system for the Suzuki–Miyaura cross-coupling reactions of aryl bromides with phenylboronic acid in the presence of Cs2CO3. |
| Keywords: | Palladium Imidazol-2-ylidene Suzuki–Miyaura reaction Aryl bromides Catalysis |
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