New Lactone and Xanthone Derivatives Produced by a Mangrove Endophytic Fungus Phoma sp. SK3RW1M from the South China Sea |
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| Authors: | Jia‐Hui Pan Juan‐Juan Deng Yi‐Guang Chen Jun‐Ping Gao Yong‐Cheng Lin Zhi‐Gang She Yu‐Cheng Gu |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, Sun Yat‐sen University, 135 Xingang West Road, Guangzhou 510275, P.?R. China (phone/fax: +86‐20‐84039623);2. Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, UK RG42?6EY |
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| Abstract: | A new lactone, 1,8‐dihydroxy‐10‐methoxy‐3‐methyldibenzo[b,e]oxepine‐6,11‐dione ( 1 ), and two new xanthones, 1‐hydroxy‐8‐(hydroxymethyl)‐6‐methoxy‐3‐methyl‐9H‐xanthen‐9‐one ( 2 ) and 1‐hydroxy‐8‐(hydroxymethyl)‐3‐methoxy‐6‐methyl‐9H‐xanthen‐9‐one ( 3 ), were isolated from a mangrove endophytic fungus Phoma sp. SK3RW1M collected from the South China Sea. This is the first report on xanthone derivatives isolated as secondary metabolites from Phoma species. Their structures were elucidated by spectroscopic methods, mainly 1D‐ and 2D‐NMR techniques, and the structure of compound 2 was confirmed by X‐ray crystallography. Cytotoxicity assays showed that compounds 1 – 3 were inactive against KB and KBv200 cells. |
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| Keywords: | Phoma species Fungi Lactones Mangroves Xanthones |
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