Anthraquinones and Lignans from Cassia occidentalis |
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| Authors: | Shi‐Fei Li Ying‐Tong Di Yue‐Hu Wang Cheng‐Jian Tan Xin Fang Yu Zhang Yong‐Tang Zheng Ling Li Hong‐Ping He Shun‐Lin Li Xiao‐Jiang Hao |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.?R. China, (phone: +86‐871‐5223263);2. Graduate School of Chinese Academy of Sciences, Beijing 100049, P.?R. China;3. Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P.?R. China;4. Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming 650031, P.?R. China |
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| Abstract: | One new anthraquinone glycoside, 6‐O‐(α‐L ‐rhamnopyranosyl‐(1→6)‐β‐d‐ glucopyranosyl)emodin ( 1 ), and two new sesquilignans, seslignanoccidentaliols A ( 2 ) and B ( 3 ), were isolated from the whole plant of Cassia occidentalis. The structures of the new compounds were established by means of spectroscopic methods, especially 2D‐NMR data (1H,1H‐COSY, HMQC, HMBC, and ROESY), as well as HR‐ESI‐MS analysis. One previously reported sesquilignan, erythro‐guaiacylglycerol‐β‐O‐4′‐(5′)‐methoxylariciresinol, was revised to be seslignanoccidentaliol A ( 2 ). The 6‐O‐(α‐L ‐rhamnopyranosyl‐(1→6)‐β‐d‐ glucopyranosyl)emodin ( 1 ) exhibited moderate anti‐HIV‐1 activity with an EC50 value of 2.90 μg/ml and a therapeutic‐index (TI) value of 260. |
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| Keywords: | Cassia occidentalis Anthraquinones Anthraquinone glycosides Glycosides Lignans Sesquilignans Seslignanoccidentaliols A and B Anti‐HIV‐1 activity |
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