| KLVFF peptide functionalized nanoparticles capture Aβ42 by co-assembly for decreasing cytotoxicity |
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| 作者姓名： | Peipei Yang Chao Yang Kuo Zhang Lei Wang Hao Wang |
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| 作者单位： | CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology(NCNST), Beijing 100190, China |
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| 摘 要： | The bis(pyrene)-Lys-Leu-Val-Phe-Phe-Gly-poly ethylene glycol (BP-KLVFFG-PEG) based nanoparticles capture Aβ42 by recognition and co-assembly, the length of PEG chain in which leads to different morphologies of coassemblies and capture efficiency. The co-assembly strategy shows a decrease of cytotoxicity, potentially for Alzheimer's disease treatment.
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| 关 键 词： | Co-assembly Morphology Capture Nanoparticles A&beta |
| 收稿时间： | 20 July 2018 |
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