Rhodium(III)-catalysed,redox-neutral C(sp2)-H alkenylation using pivalimide as a directing group with internal alkynes |
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| Authors: | Subban Kathiravan Ian A. Nicholls |
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| Affiliation: | 1. Bioorganic & Biophysical Chemistry Laboratory, Department of Chemistry & Biomedical Sciences and Linnaeus University Centre for Biomaterials Chemistry, Linnaeus University, SE-391 82 Kalmar, Sweden;2. Department of Chemistry – BMC, Uppsala University, SE-75123 Uppsala, Sweden |
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| Abstract: | In the presence of [RhCp1Cl2]2, N-pivaloyl anilines react with internal alkynes to give the corresponding 2-alkenylpivalimides under redox neutral conditions through C-H activation. This redox neutral hydroarylation, which does not require an external organic acid, unlocks a regioselective synthetic route to 2-alkenyl anilines and is generally applicable to diversely substituted electron rich and electron poor pivalimides. |
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| Keywords: | Hydroarylation Internal alkynes Redox-neutral Rhodium catalysis Pivalimide |
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