New Chemical Constituents from Borreria verticillata (Rubiaceae) |
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| Authors: | Vinicius F Moreira Rodrigo R Oliveira Leda Mathias Raimundo Braz‐Filho Ivo J Curcino Vieira |
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| Institution: | 1. Setor de Química de Produtos Naturais, Universidade Estadual do Norte Fluminense Darcy, Ribeiro, 28013‐602, Campos dos Goytacazes, Rio de Janeiro, Brazil, (phone: +55‐22‐27397046;2. fax: +55‐22‐27397248);3. Pesquisador Visitante Emérito‐FAPERJ/UENF/UFRRJ |
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| Abstract: | A phytochemical study on Borreria verticillata has led to the isolation of two novel simple indole alkaloids, 6‐methoxy‐4‐(3‐methylbut‐2‐en‐1‐yl)‐1H‐indole, named verticillatine A ( 1 ), and 1‐(1H‐indol‐6‐yl)‐3‐methylbutan‐1‐one, named verticillatine B ( 2 ), one new iridoid, 6′‐O‐(2‐glyceryl)scandoside methyl ester ( 3 ), with the glycerol unit linked to a glucose unit, and two known ones, asperuloside ( 4 ) and scandoside methyl ester ( 5 ). The structures of these compounds were elucidated on the basis of spectroscopic‐data analyses, mainly 1H‐ and 13C‐NMR, including 2D experiments (1H,1H‐COSY, NOESY, HMBC, and HMQC), and HR‐ESI‐MS. |
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| Keywords: | Borreria verticillata Verticillatines A and B Indole alkaloids Iridoids Alkaloids |
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