Microwave‐Assisted Synthesis of Novel 2,4‐Dihydro‐5‐[4‐(trifluoromethyl)phenyl]‐3H‐1,2,4‐triazol‐3‐ones and Potentiometric Determination of Their pKa in Nonaqueous Solvents |
| |
| Authors: | Musa Özil Fatih İslamoğlu Emre Menteşe Bahittin Kahveci |
| |
| Affiliation: | 1. Department of Chemistry, Faculty of Art and Science, Rize University, Rize, 53100, Turkey, (phone: +90?464?223?53?75;2. fax: +90?464?223?53?76) |
| |
| Abstract: | The novel 4‐amino‐ or 4‐aryl‐substituted 2,4‐dihydro‐5‐[(4‐trifluoromethyl)phenyl]‐3H‐1,2,4‐triazol‐3‐ones 3a – 3g were synthesized by reaction of N‐(ethoxycarbonyl)‐4‐(trifluoromethyl)benzenehydrazonic acid ethyl ester ( 2 ) and primary amines or hydrazine by microwave irradiation. Compounds 3a – 3g were potentiometrically titrated with tetrabutylammonium hydroxide (Bu4NOH) in four nonaqueous solvents, i.e., iPrOH, tBuOH, MeCN, and N,N‐dimethylformamide (DMF). Also half‐neutralization potential values and the corresponding pKa values were determined in all cases. |
| |
| Keywords: | Microwave‐assisted synthesis 3H‐1,2,4‐Triazol‐3‐ones, 2,4‐dihydro‐ Potentiometry |
|
|
