A New Nortriterpene from the Root of Celastrus hypoleucus |
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| Authors: | Hong Wang Xuan Tian Guo Qing Ying |
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| Affiliation: | 1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P.?R. China, (phone/fax: +86‐571‐88871029);2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.?R. China |
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| Abstract: | A new nortriterpene, 2‐hydroxy‐3‐methyl‐21‐oxo‐12,24‐dinor‐D : B‐friedooleana‐1,3,5(10),7‐tetraen‐29‐oic acid ( 1 ), was isolated from the root of Celastrus hypoleucus, together with the two known compounds, celastorol ( 2 ) and pristimerine ( 3 ). Their structures were elucidated on the basis of spectroscopic analyses. Compounds 1 – 3 exhibited in vitro significant antioxidant (against lipid peroxidation; by the TBARS method) and antitumor activities (against cancer cell lines P‐388, A‐549, HL‐60, and BEL‐7402). |
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| Keywords: | Celastrus hypoleucus Antioxidant activity Antitumor activity Nortriterpenes |
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