The Baylis–Hillman Adducts as Valuable Source for One‐Pot Multi‐Step Synthesis: A Facile Synthesis of Substituted Piperidin‐2‐ones |
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| Authors: | Deevi Basavaiah Raju Jannapu Reddy Dandamudi V. Lenin |
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| Affiliation: | School of Chemistry, University of Hyderabad, Hyderabad‐500?046, India, (fax: +91‐40‐23012460) |
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| Abstract: | A facile, convenient, and one‐pot multi‐step synthesis of substituted piperidin‐2‐ones from the Baylis–Hillman alcohols derived from various aldehydes and acrylonitrile, involving Johnson–Claisen rearrangement, reduction of an α,β‐unsaturated nitrile moiety into the saturated amine‐skeleton, followed by cyclization, in an operationally simple procedure, is described. |
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| Keywords: | Baylis– Hillman adducts Piperidin‐2‐ones Multicomponent reactions Johnson– Claisen rearrangement X‐Ray crystallography |
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