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Study on the Constituents of Roots of Aceriphyllum rossii |
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| Authors: | Le Thi Kim Van Tran Manh Hung Soo Hyun Kim Jin Cheol Kim MinKyun Na Hyun Ju Jung Seung Jun Kwack Kee Tae Kweon Jae Sue Choi Hyeong Kyu Lee KiHwan Bae Byung‐Sun Min |
| Institution: | 1. College of Pharmacy, Catholic University of Daegu, Gyeongsan 712‐702, Korea, (phone: +82‐53‐850‐3613;2. fax: +82‐53‐850‐3602);3. Korea Research Institute of Bioscience and Biotechnology, Daejeon 305‐600, Korea;4. Korea Research Institute of Chemical Technology, Daejeon 305‐600, Korea;5. College of Pharmacy, Yeungnam University, Gyeongsan 712‐749, Korea;6. Department of Oriental Pharmacy, Wonkwang University, Iksan 570‐749, Korea;7. National Institute of Toxicological Research, Seoul 122‐704, Korea;8. Faculty of Food Science and Biotechnology, Pukyung National University, Busan 608‐737, Korea;9. College of Pharmacy, Chungnam National University, Daejeon 305‐764, Korea |
| Abstract: | A new stereoisomer of a tetrahydrofuranoid lignan, acerifuranoid A ( 1 ), and two new oleanane‐type triterpenoids, aceriphyllic acids J and K ( 2 and 3 ), were isolated from the roots of Aceriphyllum rossii. Their structures were elucidated on the basis of spectroscopic analyses and chemical evidence. These isolated compounds exhibited weak cytotoxic activity against various cancer cell lines with IC50>150 μM . |
| Keywords: | Aceriphyllum rossii Tetrahydrofuranoid lignans Lignans Acerifuranoid A Oleanane‐type triterpenoids Aceriphylic acids J and K Triterpenoids Cytotoxic activity |