Two New Steroidal Saponins from the Processed Polygonatum kingianum |
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| Authors: | He‐Shui Yu Bai‐Ping Ma Xin‐Bo Song Li‐Ping Kang Tao Zhang Jing Fu Yang Zhao Cheng‐Qi Xiong Da‐Wei Tan Li‐Juan Zhang Jie Zhang Kate Yu |
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| Institution: | 1. Beijing Institute of Radiation Medicine, No. 27 Tai‐Ping Road, Haidian District, Beijing 100850, P.?R. China (phone: +86‐10‐68210077 ext. 930265;2. fax: +86‐10‐68214653);3. Tianjin University of Traditional Chinese Medicine, No. 88 Yuquan Road, Nankai District, Tianjin 300193, P.?R. China (phone: +86‐22‐27494976;4. fax: +86‐22‐27460231);5. Waters Corporation, Milford, MA 01757, U.S.A. |
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| Abstract: | Two new spirostanol saponins, kingianoside I ( 1 ) and kingianoside K ( 2 ), corresponding to (3β,23S,25R)‐23‐hydroxy‐12‐oxospirost‐5‐en‐3‐yl 4‐O‐β‐D ‐glucopyranosyl‐β‐D ‐galactopyranoside ( 1 ) and (3β,25R)‐7‐oxospirost‐5‐en‐3‐yl α‐L ‐arabinofuranosyl‐(1→4)‐6‐deoxy‐α‐L ‐mannopyranosyl‐(1→2)]‐β‐D ‐glucopyranoside ( 2 ), along with 13 known compounds, daucosterol, (25R)‐kingianoside G, (25RS)‐kingianoside A, pratioside D1, (25RS)‐pratioside D1, (25S)‐kingianoside C, kingianoside C, ginsenoside Rb1, saponins Tb and Pb, dioscin, gracillin, and saponin Pa, were isolated from the processed rhizomes of Polygonatum kingianum. The structures of the new compounds were elucidated by detailed spectroscopic analyses, including 1D‐ and 2D‐NMR techniques, and chemical methods. Compound 2 contains a novel unusual spirostanol saponin aglycone. Ginsenoside Rb1 and saponin Tb were isolated for the first time from the genus Polygonatum. The 13 known compounds were detected for the first time in the processed Polygonatum kingianum. |
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| Keywords: | Polygonatum kingianum Saponins Steroids Kingianosides I and K |
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