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Synthesis of Novel Polycyclic Indole‐Annulated Thiopyranocoumarin Derivatives via Domino Knoevenagel–Hetero‐Diels–Alder Reaction in Aqueous Media |
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| Authors: | Firouz Matloubi Moghaddam Mostafa Kiamehr Salman Taheri Zohreh Mirjafary |
| Institution: | 1. Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, P.?O. Box 11155‐9516, Tehran, Iran, (phone: +98‐21‐66165309;2. fax: +98‐21‐66012983) |
| Abstract: | An efficient synthesis of polycyclic indole derivatives is achieved via domino Knoevenagel–hetero‐Diels–Alder reaction of O‐acrylated salicylaldehyde derivatives with dihydroindole‐2‐thiones in H2O as solvent. The products are formed in good‐to‐excellent yields with high regio‐ and stereoselectivity. |
| Keywords: | Indole derivatives Knoevenagel reaction Hetero‐Diels– Alder reaction Indole‐2‐thiones dihydro‐ Salicylaldehydes O‐acrylated‐ Thiopyranocoumarin |