Diketopiperazine Alkaloids from Penicillium spp. HS‐3, an Endophytic Fungus in Huperzia serrata |
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Authors: | Wei‐Guang Shan You‐Min Ying Hai‐Ning Yu Wen‐Hong Liu Zha‐Jun Zhan |
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Affiliation: | 1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P.?R. China, (phone: +86‐571‐88871075);2. Zhejiang Chinese Medical University, Hangzhou 310053, P.?R. China |
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Abstract: | Cultivation of the fungus Penicillium spp. HS‐3, an endophytic fungus from the stems of Huperzia serrata, led to the isolation of a new diketopiperazine alkaloid, named as tryhistatin ( 1 ), together with three known ones, 2 – 4 , all of which share a similar backbone. The structure of 1 was established by detailed interpretation of the 1D‐ and 2D‐NMR spectra, and HR‐ESI‐MS data. Furthermore, 1D‐ and 2D‐NMR experiments were employed to elucidate the structure of 2 which was deduced previously only on the basis of the LC/MS method. In this article, we confirmed the correctness of the previously reported structure and made a complete assignment of the NMR signals of 2 for the first time. |
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Keywords: | Penicillium spp. HS‐3 Huperzia serrata Alkaloids Diketopiperazine alkaloids Tryhistatin |
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