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Dual pH and glucose sensitive gel gated mesoporous silica nanoparticles for drug delivery |
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| Authors: | Wenxia Gao Yalong Hu Long Xu Miaochang Liu Huayue Wu Bin He |
| Affiliation: | National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China |
| Abstract: | A low molecular weight gelator with dual pH and glucose sensitive moieties was synthesized. The gelator penetrated in the mesopores of silica nanoparticles (MSNs) and formed low molecular weight gel (LMWG) as gate to fabricate dual pH and glucose responsive nano drug delivery system. Antidiabetic drug was loaded in the gel caped MSNs, the drug release was responsive to the pH and glucose levels and the drug release could be controlled via the stimuli sensitivity of gel. |
| Keywords: | Low-molecular-weight gel Glucose/pH sensitive Gate controller Mesoporous silica nanoparticles Controlled release |
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