Four Novel Diterpenoids from Crinipellis sp. 113 |
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| Authors: | Yao‐Yao Li Yue‐Mao Shen |
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| Affiliation: | 1. Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering;2. Xiamen Engineering Research Center of Marine Microbial Drug Discovery;3. Fujian Engineering Laboratory for Pharmaceuticals;4. School of Life Sciences, Xiamen University, Xiamen, No. 422 South Siming Road, Fujian 361005, P.?R. China (phone: +86‐592‐2184180;5. fax: +86‐592‐2181722) |
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| Abstract: | Four novel diterpenoids, namely (4β)‐4,4‐O‐dihydrocrinipellin A ( 1 ), (4β,8α)‐4,4‐O,8,8‐O‐tetrahydrocrinipellin B ( 2 ), crinipellin C ( 3 ), and crinipellin D ( 4 ), along with three known ones, (3β,4β)‐3,3‐C,4,4‐O‐tetrahydrocrinipellin A ( 5 ), (4β)‐4,4‐O‐dihydrocrinipellin B ( 6 ), and phlebiakauranol alcohol, were isolated from the fungal strain Crinipellis sp. 113. Their structures were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR experiments, and by HR‐Q‐TOF mass spectrometry. Antitumor and antibacterial assays with the novel compounds 1 – 4 were carried out, showing moderate activities against HeLa cells and no effects on the growth of tested bacteria or yeast. |
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| Keywords: | Crinipellis sp. 113 Diterpenoids Dihydrocrinipellin A Tetrahydrocrinipellin B Crinipellins C and D Antitumor activity |
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