A New Isofuranonaphthalenone and Benzopyrans from the Endophytic Fungus Nodulisporium sp. A4 from Aquilaria sinensis |
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| Authors: | Zheng‐Chao Wu Dong‐Li Li Yu‐Chan Chen Wei‐Min Zhang |
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| Affiliation: | 1. Guangdong Provincial Open Laboratory of Applied Microbiology, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou 510070, P.?R. China (phone: +86‐20‐37656321;2. fax: +86‐20‐87687286);3. South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P.?R. China;4. Graduate School of the Chinese Academy of Sciences, Beijing 100049, P.?R. China |
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| Abstract: | A new isofuranonaphthalenone, (7R*,8S*)‐3,6,7,8‐tetrahydro‐4,7,8‐trihydroxynaphtho[2,3‐c]furan‐5(1H)‐one ( 1 ), and a new benzopyran, (2R*,4R*)‐3,4‐dihydro‐4‐methoxy‐2‐methyl‐2H‐1‐benzopyran‐5‐ol ( 2 ), together with four known related analogs, 3 – 6 , were isolated from the culture of Nodulisporium sp. A4, an endophytic fungus from the stem of Aquilaria sinensis (Lour.) Gilg . The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature reports. The isolated compounds 1 – 6 were evaluated for their cytotoxic activities against the NCI‐H460 and SF‐268 tumor cell lines. |
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| Keywords: | Nodulisporium sp. A4 Aquilaria sinensis Fungi Isofuranonaphthalenones Benzopyrans |
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