Synthesis of methyl 7-aryl-6-(2-thenoyl)-4,7-dihydro-tetrazolo[1,5-<Emphasis Type="Italic">a</Emphasis>]pyrimidine-5-carboxylates and their reaction with hydrazine hydrate |
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| Authors: | V L Gein V V Mishunin E P Tsyplyakova M I Vakhrin P A Slepukhin |
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| Institution: | 1.Perm State Pharmaceutical Academy,Federal Health and Social Development Agency,Perm,Russia;2.Perm Institute (Branch),Russian State University of Trade and Economics,Perm,Russia;3.Postovskii Institute of Organic Synthesis, Ural Division,Russian Academy of Sciences,Yekaterinburg,Russia |
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| Abstract: | Fusion of methyl 4-(2-thienyl)-2,4-dioxobutanoate with 1H-tetrazol-5-amine monohydrate and aromatic aldehyde gave methyl 7-aryl-6-(2-thenoyl)-4,7-dihydrotetrazolo1,5-a]pyrimidine-5-carboxylates which reacted with an equimolar amount of hydrazine hydrate at 180–190°C under solvent-free conditions
to produce 9-aryl-8-(2-thienyl)-4,9-dihydrotetrazolo1′,5′: 1,2]pyrimido4,5-d]pyridazin-5(6H)-ones. |
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