Manganese-Catalyzed Chemoselective Coupling of Secondary Alcohols,Primary Alcohols and Methanol |
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| Authors: | Jun Tang Jingxi He Prof?Dr Sheng-Yin Zhao Prof?Dr Weiping Liu |
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| Institution: | State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Key Lab of Science and Technology of Eco-Textile, Ministry of Education, College of Chemistry and Chemical Engineering, Donghua University, Shanghai, 201620 China |
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| Abstract: | Herein, we report a manganese-catalyzed three-component coupling of secondary alcohols, primary alcohols and methanol for the synthesis of β,β-methylated/alkylated secondary alcohols. Using our method, a series of 1-arylethanol, benzyl alcohol derivatives, and methanol undergo sequential coupling efficiently to construct assembled alcohols with high chemoselectivity in moderate to good yields. Mechanistic studies suggest that the reaction proceeds via methylation of a benzylated secondary alcohol intermediate to generate the final product. |
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| Keywords: | Alcohols Homogeneous Catalysis Manganese Methylation Three-Component Coupling |
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