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Inside Cover: Parahydrogen-Induced Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation (Angew. Chem. Int. Ed. 5/2023) |
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| Authors: | Christopher Nelson Dr Andreas B Schmidt Isaiah Adelabu Shiraz Nantogma Prof?Dr Valerij G Kiselev Abubakar Abdurraheem Henri de Maissin Dr Sören Lehmkuhl Prof?Dr Stephan Appelt Prof Thomas Theis Prof Eduard Y Chekmenev |
| Institution: | 1. Department of Chemistry, North Carolina State University, 27695-8204 Raleigh, NC, USA
These authors contributed equally to this work.;2. Division of Medical Physics, Department of Radiology, Medical Center, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106 Freiburg, Germany;3. Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, 48202 Detroit, MI, USA;4. Institute of Microstructure Technology, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, 76344 Karlsruhe, Germany;5. Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, 52056 Aachen, Germany;6. Department of Chemistry, North Carolina State University, 27695-8204 Raleigh, NC, USA |
| Abstract: | The feasibility of Carbon-13 Radiofrequency (RF) Amplification by Stimulated Emission of Radiation (C-13 RASER) is demonstrated on a bolus of liquid hyperpolarized ethyl 1-13C]acetate. Hyperpolarized ethyl 1-13C]acetate was prepared via pairwise addition of parahydrogen to vinyl 1-13C]acetate and polarization transfer from nascent parahydrogen-derived protons to the carbon-13 nucleus via magnetic field cycling yielding C-13 nuclear spin polarization of approximately 6 %. RASER signals were detected from samples with concentration ranging from 0.12 to 1 M concentration using a non-cryogenic 1.4T NMR spectrometer equipped with a radio-frequency detection coil with a quality factor (Q) of 32 without any modifications. C-13 RASER signals were observed for several minutes on a single bolus of hyperpolarized substrate to achieve 21 mHz NMR linewidths. The feasibility of creating long-lasting C-13 RASER on biomolecular carriers opens a wide range of new opportunities for the rapidly expanding field of C-13 magnetic resonance hyperpolarization. |
| Keywords: | Carbon-13 Hyperpolarization NMR Spectroscopy Parahydrogen RASER |