|
|||||
|
|
Palladium-Catalyzed Asymmetric Hydrogenolysis of Aryl Triflates for Construction of Axially Chiral Biaryls |
|
| Authors: | Xiang Li Gao-Wei Wang Li-Xia Liu Prof?Dr Chang-Bin Yu Prof?Dr Yong-Gui Zhou |
| Institution: | 1. Zhang Dayu School of Chemistry, Dalian University of Technology, 2 Linggong Road, 116024 Dalian, P.?R. China
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, P.?R. China;2. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, P.?R. China;3. Zhang Dayu School of Chemistry, Dalian University of Technology, 2 Linggong Road, 116024 Dalian, P.?R. China |
| Abstract: | Here we report the first palladium-catalyzed asymmetric hydrogenolysis of readily available aryl triflates via desymmetrization and kinetic resolution for facile construction of axially chiral biaryl scaffolds with excellent enantioselectivities and s selectivity factors. The axially chiral monophosphine ligands could be prepared from these chiral biaryl compounds and were further applied to palladium-catalyzed asymmetric allylic alkylation with excellent ee values and high branched and linear ratio, which demonstrated the potential utility of this methodology. |
| Keywords: | Aryl Triflates Asymmetric Hydrogenolysis Axially Chiral Biaryls Desymmetrization Palladium |