| Institution: | 1. School of Chemistry and Chemical Engineering, Henan Normal University, Pingyuan Laboratory, Xinxiang, Henan, 453007 P. R. China
These authors contributed equally to this work.;2. School of Chemistry and Chemical Engineering, Henan Normal University, Pingyuan Laboratory, Xinxiang, Henan, 453007 P. R. China;3. International Scientific and Technological Cooperation Base of Chiral Chemistry, Henan University, Kaifeng, Henan, 475004 P. R. China |
| Abstract: | A chiral Brønsted acid-catalysed asymmetric hydrophosphinylation of 2-vinylazaarenes by secondary phosphine oxides is described. A variety of P-chiral 2-azaaryl-ethylphosphine oxides are synthesized with high yields and ees, of which both the substituents of phosphines and azaarenes can be flexibly modulated, underscoring an exceptionally broad scope of substrates. These adducts are valuable to asymmetric metal catalysis since the resultant P-chiral tertiary phosphines from the reduction of them are verified as a kind of effective C1-symmetric chiral 1,5-hybrid P,N-ligands. Importantly, this catalysis platform enables the generic and efficient kinetic resolution of P-chiral secondary phosphine oxides. It thus provides an expedient approach to access the enantiomers of the P-chiral tertiary phosphine oxides derived from asymmetric hydrophosphinylation, further improving the utility of the method. |
