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Regioselective Difunctionalization and Annulation of Ynamide
Authors:Dr Shubham Dutta  Dr Rajendra K Mallick  Prof?Dr Akhila K Sahoo
Institution:1. School of Chemistry, University of Hyderabad, Gachibowli, Hyderabad, Telangana, 500046 India;2. School of Chemistry, University of Bristol, Bristol, BS8 1TS UK
Abstract:The use of ynamides in organic synthesis has gained significant attention due to their ability to provide access to complex molecular structures through transformations such as 1,2-difunctionalization and annulation reactions. These reactions enable the formation of highly functionalized N-bearing olefins and unusual N-bearing heterocycles. In this minireview, we present a systematic overview of the regioselective difunctionalization and annulation reactions of ynamides. We discuss the multi-component reactions, and radical-triggered functionalizations across the ynamides carbon–carbon multiple bonds and the use of bifunctional reagents in annulation of ynamides, highlighting their potential in expanding the substrate scope. Furthermore, we provide insights into the mechanistic breakthroughs that have been achieved in recent years in the development of these reactions. Finally, we emphasize the promising future prospects of ynamides as versatile building blocks for the synthesis of complex molecular architectures.
Keywords:Chelation  Keteniminium  Radical  Regioselective 1  2-Difunctionalization  Ynamide
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