Oxygen-Deficient Molybdenum Oxide Nanosensitizers for Ultrasound-Enhanced Cancer Metalloimmunotherapy |
| |
| Authors: | Yuanjie Wang Dr. Fei Gong Zhihui Han Huali Lei Yangkai Zhou Shuning Cheng Xiaoyuan Yang Tianyi Wang Dr. Li Wang Nailin Yang Prof. Zhuang Liu Prof. Liang Cheng |
| |
| Affiliation: | 1. Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, 215123 China;2. Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, 215000 China |
| |
| Abstract: | Oxygen-deficient molybdenum oxide (MoOX) nanomaterials are prepared as novel nanosensitizers and TME-stimulants for ultrasound (US)-enhanced cancer metalloimmunotherapy. After PEGylation, MoOX-PEG exhibits efficient capability for US-triggered reactive oxygen species (ROS) generation and glutathione (GSH) depletion. Under US irradiation, MoOX-PEG generates a massive amount of ROS to induce cancer cell damage and immunogenic cell death (ICD), which can effectively suppress tumor growth. More importantly, MoOX-PEG itself further stimulates the maturation of dendritic cells (DCs) and triggeres the activation of the cGAS-STING pathway to enhance the immunological effect. Due to the robust ICD induced by SDT and efficient DC maturation stimulated by MoOX-PEG, the combination treatment of MoOX-triggered SDT and aCTLA-4 further amplifies antitumor therapy, inhibits cancer metastases, and elicits robust immune responses to effectively defeat abscopal tumors. |
| |
| Keywords: | DC Maturation Metalloimmunotherapy Molybdenum Oxide Sonodynamic Therapy cGAS-STING Pathway |
|
|
