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Heterostructures with Built-in Electric Fields for Long-lasting Chemodynamic Therapy |
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| Authors: | Dr Huilin Zhang Dr Yang Chen Dr Wei Hua Wenjun Gu Dr Hongjun Zhuang Dr Huiyan Li Dr Xingwu Jiang Prof Ying Mao Prof Yanyan Liu Prof Dayong Jin Prof Wenbo Bu |
| Institution: | 1. Departments of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040 P. R. China
Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438 P. R. China These authors contributed equally to this work.;2. School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China These authors contributed equally to this work.;3. Departments of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040 P. R. China These authors contributed equally to this work.;4. Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438 P. R. China;5. Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438 P. R. China Departments of Rehabilitation, Zhongshan Hospital, Fudan University, Shanghai, 200032 P. R. China;6. Departments of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040 P. R. China;7. Institute for Biomedical Materials & Devices (IBMD), Faculty of Science, University of Technology Sydney, New South Wales, 2007 Australia |
| Abstract: | Sustained signal activation by hydroxyl radicals (?OH) has great significance, especially for tumor treatment, but remains challenging. Here, a built-in electric field (BIEF)-driven strategy was proposed for sustainable generation of ?OH, thereby achieving long-lasting chemodynamic therapy (LCDT). As a proof of concept, a novel Janus-like Fe@Fe3O4?Cu2O heterogeneous catalyst was designed and synthesized, in which the BIEF induced the transfer of electrons in the Fe core to the surface, reducing ≡Cu2+ to ≡Cu+, thus achieving continuous Fenton-like reactions and ?OH release for over 18 h, which is approximately 12 times longer than that of Fe3O4?Cu2O and 72 times longer than that of Cu2O nanoparticles. In vitro and in vivo antitumor results indicated that sustained ?OH levels led to persistent extracellular regulated protein kinases (ERK) signal activation and irreparable oxidative damage to tumor cells, which promoted irreversible tumor apoptosis. Importantly, this strategy provides ideas for developing long-acting nanoplatforms for various applications. |
| Keywords: | Antitumor Agent Built-in Electron Field Chemodynamic Therapy Fenton Reaction Radicals |