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Record Ultralarge-Pores,Low Density Three-Dimensional Covalent Organic Framework for Controlled Drug Delivery** |
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| Authors: | Dr Yu Zhao Dr Saikat Das Taishu Sekine Haruna Mabuchi Tsukasa Irie Jin Sakai Dan Wen Prof Weidong Zhu Prof Teng Ben Prof Yuichi Negishi |
| Institution: | 1. Zhejiang Engineering Laboratory for Green Syntheses and Applications of Fluorine-Containing Specialty Chemicals, Institute of Advanced Fluorine-Containing Materials, Zhejiang Normal University, Jinhua, 321004 China
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua, 321004 China These authors contributed equally to this work.;2. Department of Applied Chemistry, Faculty of Science, Tokyo University of Science Kagurazaka, Shinjuku-ku, Tokyo, 162-8601 Japan;3. Zhejiang Engineering Laboratory for Green Syntheses and Applications of Fluorine-Containing Specialty Chemicals, Institute of Advanced Fluorine-Containing Materials, Zhejiang Normal University, Jinhua, 321004 China Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua, 321004 China;4. Zhejiang Engineering Laboratory for Green Syntheses and Applications of Fluorine-Containing Specialty Chemicals, Institute of Advanced Fluorine-Containing Materials, Zhejiang Normal University, Jinhua, 321004 China |
| Abstract: | The unique structural characteristics of three-dimensional (3D) covalent organic frameworks (COFs) like high surface areas, interconnected pore system and readily accessible active sites render them promising platforms for a wide set of functional applications. Albeit promising, the reticular construction of 3D COFs with large pores is a very demanding task owing to the formation of interpenetrated frameworks. Herein we report the designed synthesis of a 3D non-interpenetrated stp net COF, namely TUS-64, with the largest pore size of all 3D COFs (47 Å) and record-low density (0.106 g cm?3) by reticulating a 6-connected triptycene-based linker with a 4-connected porphyrin-based linker. Characterized with a highly interconnected mesoporous scaffold and good stability, TUS-64 shows efficient drug loading and controlled release for five different drugs in simulated body fluid environment, demonstrating the competency of TUS-64 as drug nanocarriers. |
| Keywords: | Covalent Organic Framework Drug Delivery Mesoporous Non-Interpenetrated Three-Dimensional |