Bile Acid Conjugates with Anticancer Activity: Most Recent Research |
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| Authors: | Maria Luisa Navacchia Elena Marchesi Daniela Perrone |
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| Institution: | 1.Institute of Organic Synthesis and Photoreactivity, National Research Council, Piero Gobetti 101, 40129 Bologna, Italy;2.Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Luigi Borsari 46, 44121 Ferrara, Italy; |
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| Abstract: | The advantages of a treatment modality that combines two or more therapeutic agents in cancer therapy encourages the study of hybrid functional compounds for pharmacological applications. In light of this, we reviewed recent works on hybrid molecules based on bile acids. Due to their biological properties, as well as their different chemical/biochemical reactive moieties, bile acids can be considered very interesting starting molecules for conjugation with natural or synthetic bioactive molecules. |
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| Keywords: | bile acids conjugates natural product hybrids anticancer agents pharmacological activity bioconjugation drug design |
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