A chemical investigation ofAchillea nobilis

From the flower heads and leaves ofAchillea nobilis collected in the flowering phase close to Balytkykol, Egindybulak region, Karaganda Province, Kazakh SSR, by extraction with chloroform and chromatography of the combined substances on a column of silica gel we have isolated a new sesquiterpene lactone anobin C₁₅H₂₀O₅, mp 175.5–177.5°C and have identified for the first time estafiatin, C₁₅H₁₈O₃, mp 102–104°C ]²⁰ –10.3° (chloroform); hanphyllin, C₁₅H₂₀O₃, mp 189°C (decomp), ] _D ²⁰ + 58.6° (c 0.39; chloroform), and 3,5-dihydroxy-6,7,8-trimethoxyflavone, C₁₈H₁₆O₇, mp 148–150°C. On the basis of chemical and spectral characteristics it has been established that anobin has the structure of 4,10-dihydroxy-2,3-epoxy-5,7(H),6(H)-guai-11(13)-en-6,12-olide. It has been established that estafiatin possesses a pronounced growth regulating activity.Deceased.Chemical and Metallurgical Institute, Academy of Sciences of the Kazakh SSR, Karaganda. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 603–607, September–October, 1984.