| HPLC法测定阿奇霉素葡萄糖注射液中阿奇霉素的含量 |
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| 引用本文： | 盛俊泰,张瑞琛,周娟. HPLC法测定阿奇霉素葡萄糖注射液中阿奇霉素的含量[J]. 化学分析计量, 2002, 11(3): 14-15 |
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| 作者姓名： | 盛俊泰 张瑞琛 周娟 |
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| 作者单位： | 1. 济南金泰制药厂,250100
2. 济南军区军事医学研究所,济南,250014 |
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| 摘 要： | 利用高效液相色谱法，以VP-ODS型色谱柱，乙腈-异丙醇-水-氨水（60：25：15：0.1)为流动相，于210nm波长处测定了阿奇霉素葡萄糖注射液中阿奇霉素葡萄糖注射液中阿奇霉素的含量。阿奇霉素的浓度在0.75-1.75mg/mL线性关系良好，线性方程的A=881910.4c-16208.2，相关系数r=0.9999。阿奇霉素的平均回收率为99.59%，测定结果的相对标准偏差为1.31%。
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| 关 键 词： | 高效液相色谱法 测定 阿奇霉素葡萄糖注射液 阿奇霉素 抗生素 药物含量测定 |
| 修稿时间： | 2002-03-02 |
DETERMINATION OF AZITHROMYCIN IN AZITHROMYCIN GLUCODE INJECTION BY HPLC |
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| Sheng Juntai,Zhang Ruichen Zhou Juan. DETERMINATION OF AZITHROMYCIN IN AZITHROMYCIN GLUCODE INJECTION BY HPLC[J]. Chemical Analysis And Meterage, 2002, 11(3): 14-15 |
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| Authors: | Sheng Juntai Zhang Ruichen Zhou Juan |
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| Abstract: | HPLC was applied to determine azithromycin in azithromycin glucode injection by VP - ODS columnm with a mobile phase of CH3CN:(CH3)2CHOH:H2O:NH3(60:25:15:0.1) at 210 nm. The concentraion of azithromycin had a linear range of 0.75 - 1.75 mg/mL,and the linear function was A =881910. 4c - 16208. 2 (r =0. 9999). The average recovery of azithromycin was 99. 59% with RSD being 1.31% . |
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| Keywords: | HPLC determination azithromycin glucode injection azithromycin content |
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