| Stereoselective Synthesis of 3(R) and 3(S)-Hydroxyeicos-4(E)-en-1-yne, a Component of the Marine Sponge Cribrochalina Vasculum |
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| 作者姓名： | Wei LU Guang Rong ZHENG Da Xin GAO and Jun Chao CAI |
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| 作者单位： | Shanghai Institute of Materia Medica，Chinese Academy of Sciences，Shanghai 200031 |
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| 摘 要： | Recently,aseriesofacetylenicalc0hols'possessingacharacteristic4-en-l-yn-3-olskeletonwasis0latedfromthemarinesp0ngeCribrochalinavasculum(Figure1)andshowedirnmnosuPpresiveandantitumoractivitiesinvitr0.1Toourknowledge,stereoselectivesynthesishasnotbeencarriedoutonthesecomPounds.WedescribehereinthestereoselectivesynthesisoftW0enantiomersof3-hydroxy-4(E)-en-l-yne(A)fromD-gluconolactoneandD-xyloserespectivelyusingacetylenictechnology.Bythepublishedmethod',theacetylenicalcohollwaspreparedfromD-gl…
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Stereoselective Synthesis of 3(R) and 3(S)-Hydroxyeicos-4(E)-en-1-yne, a Component of the Marine SpongeCribrochalina Vasculum |
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| Wei LU, Guang Rong ZHENG, Da Xin GAO and Jun Chao CAI.Stereoselective Synthesis of 3(R) and 3(S)-Hydroxyeicos-4(E)-en-1-yne, a Component of the Marine Sponge Cribrochalina Vasculum[J].Chinese Chemical Letters,1998(4). |
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| Authors: | Wei LU Guang Rong ZHENG Da Xin GAO and Jun Chao CAI |
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| Abstract: | Stereocontrolled synthesis of 3(R) and 3 (S)-hydroxyeicos-4(E)-en-1-yne has been achieved through double elimination of chloride intermediates 8 and 11, which were prepared from acetylenic alcohol intermediates 1 and 10. |
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| Keywords: | stereocontrolled synthesis 3-hydroxyeicos-4(E)-en-1-yne double elimination |
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