Thermal desorption characterisation of molecularly imprinted polymers. Part I: a novel study using direct-probe GC-MS analysis |
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Authors: | Wayne Cummins Patrick Duggan Peter McLoughlin |
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Institution: | (1) Separation Science Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology, Cork Road, Waterford, Ireland |
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Abstract: | A novel thermal desorption technique using a direct-probe device (Chromatoprobe) attached to a gas chromatograph–mass spectrometer
is presented for the thermal pretreatment, characterisation and analysis of molecularly imprinted polymers. The technique
is demonstrated as effective for the removal of volatile materials, including template and unreacted monomers, from methacrylic
acid–ethylene glycol dimethacrylate copolymers imprinted with 2-aminopyridine. Mass spectrometry is a powerful technique for
polymer bleed characterisation. Thermal desorption studies on reloaded template and related compounds are reported as a means
of assessing polymer morphology, specific binding by imprinted polymers compared with reference non-imprinted polymers and
selective binding by an imprinted polymer for its template. Calibration studies on the thermal desorption technique using
an internal standard are presented with R
2 > 0.999. The technique provides a novel method for assessment of polymer thermal stability, composition and morphology. |
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Keywords: | Molecular imprinting Thermal desorption Direct probe gas chromatography– mass spectrometry Chromatoprobe Polymer characterization Aminopyridine |
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