Characterization and application of the fac-[188Re(CO)3(H2O)3]+ core |
| |
| Authors: | Jiaoyun Xia Yongxian Wang Junfeng Yu Jinquan Cao Chunfu Zhang Duanzhi Yin |
| |
| Institution: | (1) Radiopharmaceutical Research Center, Shanghai Institute of Applied Physics, Graduate School of the Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P.R. China;(2) Radiopharmaceutical Research Center, Shanghai Institute of Applied Physics, Graduate School of the Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P.R. China;(3) Radiopharmaceutical Research Center, Shanghai Institute of Applied Physics, Graduate School of the Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P.R. China;(4) Radiopharmaceutical Research Center, Shanghai Institute of Applied Physics, Graduate School of the Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P.R. China;(5) Shanghai Institute of Nuclear Research, Radiopharmaceutical Research Center, Shanghai Institute of Applied Physics, Graduate School of the Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P.R. China;(6) Radiopharmaceutical Research Center, Shanghai Institute of Applied Physics, Graduate School of the Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P.R. China |
| |
| Abstract: | Summary Fac-188Re(CO)3(H2O)3]+ was synthesized with an overall radiochemical yield of 80±5%, and more than 95% radiochemical purity after a QMA Sep-Pak
column separation. Fac-Re(CO)3(H2O)3]+ was also synthesized as a reference sample. The structure of the precursor, fac-188Re(CO)3(H2O)3]+, was confirmed by high performance of liquid chromatography (HPLC). MN-His (magnetic nanoparticles coated with silica and
modified with an amino silane coupling agent, N-3-(trimethyoxysilyl)propyl]-ethylenediamine (SG-Si900) and immobilized with
histidine) was labeled with fac-188Re(CO)3(H2O)3]+ and an initial animal test of MN-His was conducted for a magnetic targeting study. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
