Direct microanalysis by negative ion fast atom bombardment mass spectrometry |
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Institution: | Center of Advanced Instrumental Analysis, Faculty of Pharmaceutical Sciences, Kyushu University 62, Fukuoka 812, Japan |
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Abstract: | In negative ion fast atom bombardment (FAB) mass spectrometry, the use of a liquid matrix comprised of 15-crown-5—glycerol (1:10, v/v) enabled the molecular weight determination of small amounts of non-volatile acidic molecules. This ionization process could result in detection limits of less than one-fifth of those obtained using only glycerol as matrix. The function of the matrix as a proton acceptor is emphasized. |
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