Stability and Hopf bifurcation of a delayed virus infection model with Beddington–DeAngelis infection function and cytotoxic T‐lymphocyte immune response

In this paper, a class of virus infection model with Beddington–DeAngelis infection function and cytotoxic T‐lymphocyte immune response is investigated. Time delay in the immune response term is incorporated into the model. We show that the dynamics of the model are determined by the basic reproduction number and the immune response reproduction number . If , then the infection‐free equilibrium is globally asymptotically stable. If , then the immune‐free equilibrium is globally asymptotically stable. If , then the stability of the interior equilibrium is investigated. We conclude that Hopf bifurcation occurs as the time delay passes through a critical value. Numerical simulations are carried out to support our theoretical conclusion well. Copyright © 2015 John Wiley & Sons, Ltd.