A mathematical model of a P53 oscillation network triggered by DNA damage |
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Authors: | Xia Jun-Feng and Jia Ya |
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Institution: | Department of Physics and Institute of Biophysics, Central China Normal University, Wuhan 430079, China |
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Abstract: | Taking the interaction between a DNA damage repair module, an ATM
module, and a P53--MDM2 oscillation module into account, this paper
presents a mathematical model of a P53 oscillation network triggered
by a DNA damage signal in individual cells. The effects of the DNA
damage signal and the delay time of P53-induced MDM2 expression on
the behaviours of the P53 oscillation network are studied. In the
oscillatory state of the P53--MDM2 oscillator, it is found that the
pulse number of P53--P oscillation increases with the increase of the
initial DNA damage signal, whereas the amplitude and the period of
P53--P oscillation are fixed for different initial DNA damage
signals, and the period numbers of P53--P oscillations decrease
with the increase of time delay of MDM2 expression induced by P53.
These theoretical predictions are consistent with previous
experimental results. The combined negative feedback of P53--MDM2
with the time delay of P53-induced MDM2 expression causes oscillation
behaviour in the P53 network. |
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Keywords: | P53 oscillation network DNA damage signal time delay kinetic model |
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