Sulfur ylides. 10. Modified method for the synthesis of pyrrolizine- and indolizinediones |
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| Authors: | Lakeev S. N. Mullagalin I. Z. Maidanova I. O. Galin F. Z. Tolstikov G. A. |
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| Affiliation: | (1) Ufa Research Center of the Russian Academy of Sciences, Institute of Biology, 69 prosp. Oktyabrya, 450054 Ufa, Russian Federation;(2) Ufa Research Center of the Russian Academy of Sciences, Institute of Organic Chemistry, 71 prosp. Oktyabrya, 450054 Ufa, Russian Federation |
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| Abstract: | A modified method for the synthesis of derivatives of pyrrolizinedione and indolizinedione was proposed. The method is based on the intramolecular cyclization of keto-stabilized sulfur ylides generated in situ from diazo ketones and Me2S in the presence of Rh2(OAc)4. |
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| Keywords: | keto-stabilized sulfonium ylides diazo ketone dimethyl sulfide Rh2(OAc)4 intramolecular cyclization 3-benzyl-1-methylthio-3H-pyrrole[2,1-a]isoindole-2,5-dione 1-methylthio-3,4-dihydropyrido[2,1-a]isoindole-2,6-dione |
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