| 聚乙二醇-聚苯乙烯接枝共聚物的合成及其接肽反应性能 |
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| 引用本文： | 李赫,梁逊. 聚乙二醇-聚苯乙烯接枝共聚物的合成及其接肽反应性能[J]. 高分子学报, 1990, 0(6): 740-746 |
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| 作者姓名： | 李赫 梁逊 |
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| 作者单位： | 南开大学化学系，南开大学化学系 天津，300071，天津，300071 |
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| 摘 要： | 本文应用环氧乙烷在羟乙基树脂上的开环聚合方法,合成了凝胶和大孔型聚乙二醇-聚苯乙烯接枝共聚物(简称PEG树脂)。对不同类型载体的接肽反应动力学性能研究表明,在PEG树脂载体上的反应速度是在氯甲基化树脂上的三倍,与在溶液中进行的接肽反应速率相当。此外,还对载体性能与树脂交联度、骨架结构之间的关系进行了初步探索。
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| 关 键 词： | 固相多肽合成 羟乙基树脂 PEG树脂 开环聚合 Boc甘氨酸对硝基苯酯 |
| 收稿时间： | 1989-06-20 |
SYNTHESIS OF POLYETHYLENE GLYCOL-POLYSTYRENE GRAFT COPOLYMER AND STUDY OF ITS PROPERTY IN PEPTIDE SYNTHESIS |
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| LI He,LIANG Xun. SYNTHESIS OF POLYETHYLENE GLYCOL-POLYSTYRENE GRAFT COPOLYMER AND STUDY OF ITS PROPERTY IN PEPTIDE SYNTHESIS[J]. Acta Polymerica Sinica, 1990, 0(6): 740-746 |
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| Authors: | LI He LIANG Xun |
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| Affiliation: | Department of Chemistry; Nankai University; Tianjin; 300071 |
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| Abstract: | The gelatinous and macroporous polyethylene glycolpolystyrene graft copolymer (PEG-Resin) were synthesized by mean of ring opening polymerization of ethylene oxide on hydro-xyethyl resin. The kinetic behavior for coupling of Boc-Gly-ONP with glycine anchored to PEG-Resin, chloromethylated resin and glycine acetate in solution were determined. The experimental results showed that reaction on PEG-Resin support proceeded three times faster than that on chlorotrtethylated resin and as fast as that reaction in solution The kinetic character of gelatinous PEG-Resin was influenced by the degree of crosslinking of the copoly- mer. |
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| Keywords: | Solid phase peptide synthesis Hydroxyethy] resin PEG-Resin Ring opening polymerization Boc-Gly-ONP |
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