| 流动化学在卤化反应中的应用 |
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| 引用本文： | 刘玎,朱园园,古双喜,陈芬儿.流动化学在卤化反应中的应用[J].有机化学,2021(3):1002-1011. |
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| 作者姓名： | 刘玎 朱园园 古双喜 陈芬儿 |
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| 作者单位： | 武汉工程大学化工与制药学院绿色化工过程教育部重点实验室;武汉工程大学药物研究院;武汉工程大学化学与环境工程学院;复旦大学化学系 |
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| 基金项目： | 国家自然科学基金(Nos.21877087,21602164);新型反应器与绿色化学工艺湖北省重点实验室(武汉工程大学)开放基金(No.K202004)资助项目。 |
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| 摘 要： | 有机物的卤化反应是有机合成中最重要的转化之一.传统釜式卤化反应存在高放热及选择性差等问题,且卤化试剂一般具有毒性和腐蚀性.流动化学在传质和传热方面具有显著优势,可精确控制反应温度及试剂用量,并且可在线淬灭危险试剂,避免其暴露.按有机化合物卤化反应分类,系统地归纳了流动化学在氟化反应、氯化反应、溴化反应和碘化反应中的应用进展,并展望了其发展趋势.
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| 关 键 词： | 流动化学 微反应器 连续流 卤化 有机合成 |
Application of Flow Chemistry in Halogenation |
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| Ding Liu,Yuanyuan Zhu,Shuangxi Gu,Fener Chen.Application of Flow Chemistry in Halogenation[J].Chinese Journal of Organic Chemistry,2021(3):1002-1011. |
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| Authors: | Ding Liu Yuanyuan Zhu Shuangxi Gu Fener Chen |
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| Institution: | (Key Laboratory for Green Chemical Process of Ministry of Education,School of Chemical Engineering and Pharmacy,Wuhan Institute of Technology,Wuhan 430205;Pharmaceutical Research Institute,Wuhan Institute of Technology,Wuhan 430205;School of Chemistry and Environmental Engineering,Wuhan Institute of Technology,Wuhan 430205;Department of Chemistry,Fudan University,Shanghai 200433) |
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| Abstract: | The halogenation of organic compounds is one of the most important transformations in organic synthesis.However,there are some problems in traditional batch halogenation,such as high exothermicity,poor selectivity and the use of highly toxic and corrosive halogenating agents.Flow chemistry has its unique advantages such as high mixing efficiency,fast heat and mass transfer performance,accurate control over process parameters and enhanced process safety,reduced energy input and so on.According to the classification of halogenation of organic compounds,the main progress of flow chemistry in fluorination,chlorination,bromination and iodization is summarized systematically,and its development trend is prospected. |
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| Keywords: | flow chemistry microreactor continuous flow halogenation organic synthesis |
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