| 乙酸酐促进的[3+3]环化反应合成2-喹啉酮衍生物 |
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| 引用本文： | 赵瑜,陈卓,陈雪冰. 乙酸酐促进的[3+3]环化反应合成2-喹啉酮衍生物[J]. 有机化学, 2021, 0(2): 731-737 |
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| 作者姓名： | 赵瑜 陈卓 陈雪冰 |
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| 作者单位： | 红河学院理学院 |
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| 基金项目： | 云南省科技厅项目(NO.2017FD156);云南省高校科技创新团队资助项目. |
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| 摘 要： | 2-喹啉酮结构单元广泛存在于天然产物和药物活性分子中,并且是重要的杂环合成砌块.建立了一种乙酸酐促进下,环状β-烯胺酮和丙二酸通过[3+3]环合反应构建2-喹啉酮化合物的新方法,产率为70％～87％.该方法具有原料简单易得、操作简便、路线简洁、目标化合物可修饰性强等优点.
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| 关 键 词： | β-烯胺酮 2-喹啉酮 [3+3]环合 乙酸酐促进 |
Synthesis of 2-Quinolinone Derivatives via[3+3]Cyclization Promoted by Acetic Anhydride |
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| Zhao Yu,Chen Zhuo,Chen Xuebing. Synthesis of 2-Quinolinone Derivatives via[3+3]Cyclization Promoted by Acetic Anhydride[J]. Chinese Journal of Organic Chemistry, 2021, 0(2): 731-737 |
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| Authors: | Zhao Yu Chen Zhuo Chen Xuebing |
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| Affiliation: | (School of Science,Honghe University,Mengzi,Yunnan 661199) |
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| Abstract: | 2-Quinolinone unit is frequently found in both natural products and pharmaceuticals.Furthermore,they are important heterocycle building blocks.Herein,a novel approach to the synthesis of 2-quinolinone derivatives has been established from[3+3]cyclization of β-enaminones with malonic acid promoted by acetic anhydride with yields of 70%~87%.The reaction is particularly attractive due to following advantages:simple starting materials,operational simplicity,concise synthetic route,easy purification,highly modifiability of target molecules and so on. |
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| Keywords: | β-enaminones 2-quinolinones [3+3]cyclization acetic anhydride promoted |
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