Synthesis and properties of 1-methyl-2-phenyl-5-(2-furyl)- and 1-methyl-2-phenyl-5-(2-thienyl)imidazoles |
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| Authors: | E. V. Vlasova A. A. Aleksandrov M. M. El’chaninov |
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| Affiliation: | (1) South-Russian State Technical University, Novocherkassk, 346428, Russia;(2) Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, 344090, Russia |
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| Abstract: | 2-Phenyl-5-(2-furyl)- and 2-phenyl-5-(2-thienyl)imidazoles were synthesized by condensation of 2-furoylmethyl and 2-thenoylmethyl acetates with benzaldehyde under the conditions of Weidenhagen reaction. The products were converted to N-methyl derivatives in the KOH-acetone system. The electrophilic substitution reactions of the products (acylation, bromination, nitration, sulfonation, hydroxymethylation) were studied. |
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