A green one-pot three-component cascade reaction: the synthesis of 2-amino-5,8-dihydro-3H-pyrido[2,3-D]pyrimidin-4-ones in aqueous medium |
| |
Authors: | Ahmad Shaabani Heshmatollah Sepahvand Mahmoud Borjian Boroujeni Mohammad Tayeb Faroghi |
| |
Affiliation: | 1.Faculty of Chemistry,Shahid Beheshti University, G. C.,Tehran,Iran |
| |
Abstract: | A one-pot three-component cascade reaction for the green synthesis of a new class of 2-amino-5,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-ones was developed from the condensation of aromatic aldehydes with 2,6-diaminopyrimidin-4(3H)-one and acetophenone derivatives or various cyclic ketones in the presence of a catalytic amount of sodium carbonate in a mixture of water and ethanol at 60 ({^{circ }}hbox {C}). This reaction led to the construction of two carbon–carbon bonds and one carbon–nitrogen bond in a single synthetic step. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|